Contraindications to Liver Transplantation
Absolute | Relative |
---|---|
Uncontrolled extrahepatobiliary infection | Age >70 |
Active, untreated sepsis | Prior extensive hepatobiliary surgery |
Uncorrectable, life-limiting congenital anomalies | Portal vein thrombosis |
Active substance or alcohol abuse | Renal failure not attributable to liver disease |
Advanced cardiopulmonary disease | Previous extrahepatic malignancy (not including nonmelanoma skin cancer) |
Extrahepatobiliary malignancy (not including nonmelanoma skin cancer) | Severe obesity |
Metastatic malignancy to the liver | Severe malnutrition/wasting |
Cholangiocarcinoma | Medical noncompliance |
AIDS | HIV seropositivity with failure to control HIV viremia or CD4 <100/µL |
Life-threatening systemic diseases | Intrahepatic sepsis Severe hypoxemia secondary to right-to-left intrapulmonary shunts (Po2<50 mmHg) Severe pulmonary hypertension (mean pulmonary artery pressure >35 mmHg) Uncontrolled psychiatric disorder |