Approach to Chronic Disease is Based on Whether Glucocorticoid Therapy is Tolerated or not - Flowchart
Approach to Chronic Disease is Based on Whether Glucocorticoid Therapy is Tolerated or not - Flowchart
«Flowchart»

MANAGEMENT ALGORITHM OF CHRONIC DISEASE

Chronic disease

MANAGEMENT ALGORITHM OF CHRONIC DISEASE

Chronic disease

MANAGEMENT ALGORITHM OF CHRONIC DISEASE

MANAGEMENT ALGORITHM OF CHRONIC DISEASE

Chronic disease

Glucocorticoids tolerated

Glucocorticoids tolerated

Glucocorticoids tolerated

Glucocorticoids not tolerated

Glucocorticoids not tolerated

Glucocorticoids not tolerated

Glucocorticoids not effective

Glucocorticoids not effective

Glucocorticoids not effective

Continue therapy

Continue therapy

Continue therapy

Seek alternative agents

Seek alternative agents

Seek alternative agents

Alternative agents

Alternative agents

Alternative agents

Methotrexate
Hydroxychloroquine
Azathioprine
Leflunomide
Minocycline

Methotrexate
Hydroxychloroquine
Azathioprine
Leflunomide
Minocycline

Methotrexate
Hydroxychloroquine
Azathioprine
Leflunomide
Minocycline





End

End

End

Dose <10 mg/d

Dose <10 mg/d

Dose <10 mg/d

Yes

Yes

Yes

No

No

No

Try alternative agents

Try alternative agents

Try alternative agents

If effective, taper off glucocorticoids

If effective, taper off glucocorticoids

If effective

If not effective, consider:


Multiple agents
Infliximab
Cyclophosphamide
Thalidomide

If not effective, consider:


Multiple agents
Infliximab
Cyclophosphamide
Thalidomide


Multiple agents
Infliximab
Cyclophosphamide
Thalidomide If not effective