Management of mitral regurgitation. CAD, coronary artery disease; CRT, cardiac resynchronization therapy; ERO, effective regurgitant orifice; HF, heart failure; LVEF, left ventricular ejection fraction; LVESD, left ventricular end-systolic dimension; MR, mitral regurgitation, MV, mitral valve; MVR, mitral valve replacement; NYHA, New York Heart Association; PASP, pulmonary artery systolic pressure; RF, regurgitant fraction; RVol, regurgitant volume; and Rx, therapy. Mitral valve repair preferred over MVR when possible. (Nishimura RA et al: 2017 Focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease. Circulation 2017;135:e1159-e1195. Reprinted with permission © 2017 American Heart Association.)