Management of Opioid Overdose | |||
| Establish airway. Intubation and mechanical ventilation may be necessary. | |||
| Naloxone 0.4-2.0 mg (IV, IM, or endotracheal tube). Onset of action with IV is ∼1-2 min. | |||
| Repeat doses of naloxone if needed to restore adequate respiration or a continuous infusion of naloxone can be used. | |||
| One-half to two-thirds of the initial naloxone dose that reversed the respiratory depression is administered on an hourly basis (note: naloxone dosing is not necessary if the pt has been intubated). |