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Table 184-6

Selection of Antiepileptic Drugs

GENERALIZED-ONSET TONIC-CLONICFOCALTYPICAL ABSENCEATYPICAL ABSENCE, MYOCLONIC, ATONIC
First-line

Lamotrigine

Valproic acid

Lamotrigine

Carbamazepine

Oxcarbazepine

Phenytoin

Levetiracetam

Valproic acid

Ethosuximide

Lamotrigine

Valproic acid

Lamotrigine

Topiramate

Alternatives

Zonisamidea

Phenytoin

Levetiracetam

Carbamazepine

Oxcarbazepine

Topiramate

Phenobarbital

Primidone

Felbamate

Zonisamidea

Brivaracetam

Topiramate

Valproic acid

Tiagabinea

Gabapentina

Lacosamidea

Phenobarbital

Primidone

Felbamate

Lamotrigine

Clonazepam

Clonazepam

Felbamate

Clobazam

Rufinamide

aAs adjunctive therapy.