Causes of Hypothyroidism | |||
Primary Autoimmune hypothyroidism: Hashimoto's thyroiditis, atrophic thyroiditis Iatrogenic: 131 I treatment, subtotal or total thyroidectomy, external irradiation of neck for lymphoma or cancer Drugs: iodine excess (including iodine-containing contrast media and amiodarone), lithium, antithyroid drugs, p-aminosalicylic acid, interferon α and other cytokines, aminoglutethimide, sunitinib Congenital hypothyroidism: absent or ectopic thyroid gland, dyshormonogenesis, TSH-R mutation Iodine deficiency Infiltrative disorders: amyloidosis, sarcoidosis, hemochromatosis, scleroderma, cystinosis, Riedel's thyroiditis Overexpression of type 3 deiodinase in infantile hemangioma | |||
Transient Silent thyroiditis, including postpartum thyroiditis Subacute thyroiditis Withdrawal of thyroxine treatment in individuals with an intact thyroid After 131 I treatment or subtotal thyroidectomy for Graves' disease | |||
Secondary Hypopituitarism: tumors, pituitary surgery or irradiation, infiltrative disorders, Sheehan's syndrome, trauma, genetic forms of combined pituitary hormone deficiencies Isolated TSH deficiency or inactivity Bexarotene treatment Hypothalamic disease: tumors, trauma, infiltrative disorders, idiopathic |