Pathophysiology of Sickle Cell Crisis - Flowchart
Pathophysiology of Sickle Cell Crisis - Flowchart
«Flowchart»

Arterial PO2 oxy Hbs (soluble)

Arterial PO2 oxy Hbs (soluble)

Arterial PO2 oxy Hbs (soluble)

2

Capillary venous PO2 deoxy Hbs (polymerized)

Capillary venous PO2 deoxy Hbs (polymerized)

Capillary venous PO2 deoxy Hbs (polymerized)

2

End

End

End

Membrane changes Ca2+  influx, K leakage

Membrane changes Ca2+  influx, K leakage

Membrane changes Ca2+  influx, K leakage

2+

Stiff, viscous sickle cell

Stiff, viscous sickle cell

Stiff, viscous sickle cell

Capillary venule occlusion

Capillary venule occlusion

Capillary venule occlusion

Shortened red cell survival (hemolytic anemia)

Shortened red cell survival (hemolytic anemia)

Shortened red cell survival

Microinfarction
Ischemic tissue pain
Ischemic organ malfunction
Autoinfarction of spleen

Microinfarction
Ischemic tissue pain
Ischemic organ malfunction
Autoinfarction of spleen

Microinfarction
Ischemic tissue pain
Ischemic organ malfunction
Autoinfarction of spleen




Anemia, jaundice, gallstones, leg ulcers

Anemia, jaundice, gallstones, leg ulcers

Anemia, jaundice, gallstones, leg ulcers