Recommended Regimens and Drug Dosages for Treatment of Latent Mycobacterium tuberculosis Infectiona | ||
| REGIMEN | DOSE | ADVERSE EVENTS |
|---|---|---|
| Isoniazid alone for 6 or 9 months | Adults: 5 mg/kg (max, 300 mg) per day Children: 10 mg/kg per day | Drug-induced liver injury, nausea, vomiting, abdominal pain, skin rash, peripheral neuropathy, dizziness, drowsiness, seizure |
| Rifampin alone for 3-4 months | Adults: 10 mg/kg per day Children: 10 mg/kg (max: <45 kg, 450 mg; >45 kg, 600 mg) per day | Flu-like syndrome, skin rash, drug-induced liver injury, anorexia, nausea, abdominal pain, neutropenia, thrombocytopenia, renal reactions (e.g., acute tubular necrosis and interstitial nephritis) |
| Isoniazid plus rifampin for 3-4 months | As above | As above |
| Rifapentine plus isoniazid for 3 months | Adults and children: Isoniazid: 15 mg/kg (900 mg) weekly Rifapentine: 15-30 mg/kg (900 mg) weekly | Hypersensitivity reactions, petechial skin rash, drug-induced liver injury Anorexia, nausea, abdominal pain Hypotensive reactions |