Major Categories of Alveolar and Interstitial Inflammatory Lung Disease | |
| Lung response: Alveolitis, interstitial inflammation, and fibrosis | |
|---|---|
| Known Cause | |
| Asbestos | Radiation |
| Aspiration pneumonia | |
| Drugs (e.g., nitrofurantoin, amiodarone, methotrexate, rituximab) and chemotherapy drugs | Residual of adult respiratory distress syndrome |
Smoking-related Desquamative interstitial pneumonia Respiratory bronchiolitis-associated interstitial lung disease Langerhans cell granulomatosis (eosinophilic granulomatosis of the lung) | |
| Unknown Cause | |
| Idiopathic interstitial pneumonias | Pulmonary alveolar proteinosis |
| Idiopathic pulmonary fibrosis (usual interstitial pneumonia) | Lymphocytic infiltrative disorders (lymphocytic interstitial pneumonitis associated with connective tissue disease) |
| Eosinophilic pneumonias | |
| Acute interstitial pneumonia (diffuse alveolar damage) | Lymphangioleiomyomatosis
Amyloidosis |
Cryptogenic organizing pneumonia (bronchiolitis obliterans with organizing pneumonia) Nonspecific interstitial pneumonia | Inherited diseases Tuberous sclerosis, neurofibromatosis, Niemann-Pick disease, Gaucher disease, Hermansky-Pudlak syndrome |
Connective tissue diseases Systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, Sjögren syndrome, polymyositis-dermatomyositis | Gastrointestinal or liver diseases (Crohn disease, primary biliary cirrhosis, chronic active hepatitis, ulcerative colitis)
Graft-versus-host disease (bone marrow transplantation; solid organ transplantation) |
Pulmonary hemorrhage syndromes Goodpasture syndrome, idiopathic pulmonary hemosiderosis, isolated pulmonary capillaritis | |
| Lung response: Granulomatous | |
| Known Cause | |
| Hypersensitivity pneumonitis (organic dusts) | Inorganic dusts: beryllium, silica |
| Unknown Cause | |
| Sarcoidosis | Bronchocentric granulomatosis |
| Granulomatous vasculitides | Lymphomatoid granulomatosis |
| Granulomatosis with polyangiitis (Wegener's), allergic granulomatosis of Churg-Strauss | |