PDE5 Inhibitors for Sexual Dysfunction | ||||
| DRUG | T 1/2 | DOSE | ADVERSE EFFECTS | CONTRAINDICATIONS |
|---|---|---|---|---|
| Sildenafil | 2-5 h | 25-100 mg Starting dose 50 mg | Headache, flushing, dyspepsia Nasal congestion, altered vision | Nitrates Hypotension CV risk factors Retinitis pigmentosa Change dose with some antiretrovirals Should be on stable dose of alpha-blockers |
| Vardenafil | 4.5 h | 5-10 mg | Headache, flushing, rhinitis, dyspepsia | Same as sildenafil May have minor prolongation of QT interval Concomitant use of Class I anti-arrhythmic |
| Tadalafil | 17.5 h | 10 mg, 20 mg 2.5 or 5 mg for daily dose | Headache, dyspepsia, back pain Nasal congestion, myalgia | Same as sildenafil |
| Avandafil | 3-5 h | 50 mg, 100 mg, and 200 mg dose | Headache, flushing, nasal congestion, nasopharyngitis, back pain | Same as sildenafil |