Algorithm for Adenocarcinoma CUPS Assessment - Flowchart
Algorithm for Adenocarcinoma CUPS Assessment - Flowchart
«Flowchart»

ALGORITHM FOR ADENOCARCINOMA CUPS

Adenocarcinoma
Poorly differentiated adenocarcinoma CUPS

ALGORITHM FOR ADENOCARCINOMA CUPS

Adenocarcinoma
Poorly differentiated adenocarcinoma CUPS

ALGORITHM FOR ADENOCARCINOMA CUPS

ALGORITHM FOR ADENOCARCINOMA CUPS

Adenocarcinoma
Poorly differentiated adenocarcinoma CUPS


End

End

End

C, chemotherapy; CT, computed tomography; CUPS, cancer of unknown primary site; PET, positron emission tomography; RT, radiation therapy.

C, chemotherapy; CT, computed tomography; CUPS, cancer of unknown primary site; PET, positron emission tomography; RT, radiation therapy.

C, chemotherapy; CT, computed tomography; CUPS, cancer of unknown primary site; PET, positron emission tomography; RT, radiation therapy.

IHC to suggest “favored” primary

IHC to suggest “favored” primary

IHC to suggest “favored” primary

Isolated axillary nodes in women

Isolated axillary nodes in women

Isolated axillary nodes in women

Bone-only metastases in men (blastic)

Bone-only metastases in men (blastic)

Bone-only metastases in men

Solitary site of metastasis

Solitary site of metastasis

Solitary site of metastasis

Peritoneal carcinoma

Peritoneal carcinoma

Peritoneal carcinoma

Disseminated cancer, 2 or more sites involved

Disseminated cancer, 2 or more sites involved

Disseminated cancer

If resectable, resect with or without prior C or CRT. If unresectable, C, RT, or CRT depending on location of tumor

If resectable, resect with or without prior C or CRT. If unresectable, C, RT, or CRT depending on location of tumor

If resectable, resect with or without prior C or CRT. If unresectable, C, RT, or CRT depending on location of tumor

C, if good performance status

C, if good performance status

C, if good performance status

Breast MRI if mammogram and ultrasound are negative

Breast MRI if mammogram and ultrasound are negative

Breast MRI if mammogram and ultrasound are negative

MRI (+). Breast surgery or radiation. C and/or hormonal therapy for breast cancer.

MRI (+). Breast surgery or radiation. C and/or hormonal therapy for breast cancer.

MRI (+)

MRI (-). No surgery, consider radiation. C for breast cancer.

MRI (-). No surgery, consider radiation. C for breast cancer.

MRI (-)

If PSA not elevated, C or RT as indicated

If PSA not elevated, C or RT as indicated

If PSA not elevated

Check PSA (in tumor and serum). If elevated, Rx as prostate cancer.

Check PSA (in tumor and serum). If elevated, Rx as prostate cancer.

Check PSA

If not suggestive of primary peritoneal, GI workup for primary. C, if good performance status.

If not suggestive of primary peritoneal, GI workup for primary. C, if good performance status.

If not suggestive of primary peritoneal

If suggestive of primary peritoneal cancer, treat as ovarian cancer

If suggestive of primary peritoneal cancer, treat as ovarian cancer

If suggestive of primary peritoneal cancer