Examples of Commonly Used Nitrates | ||
| USUAL DOSE | RECOMMENDED DOSING FREQUENCY | |
|---|---|---|
| Short-acting agents | ||
| Sublingual TNG | 0.3-0.6 mg | As needed |
| Aerosol TNG | 0.4 mg (1 inhalation) | As needed |
| Sublingual ISDN | 2.5-10 mg | As needed |
| Long-acting agents | ||
| ISDN | ||
| Oral | 10-40 mg | 2-3 times daily |
| Sustained-action | 80-120 mg | 1-2 times daily |
| TNG ointment (2%) | 0.5-2 | 2-3 times daily |
| TNG transdermal patch | 0.2-0.8 mg/h | Apply in morning, remove at bedtime |
| ISMO | ||
| Oral | 20-40 mg | 2 times daily (once in the A.M., then 7 h later) |
| Sustained-action | 30-240 mg | Once daily |
Abbreviations: ISDN, isosorbide dinitrate; ISMO, isosorbide mononitrate; TNG, nitroglycerin.