Algorithm for the initial management of ARDS. Clinical trials have provided evidence-based therapeutic goals for a stepwise approach to the early mechanical ventilation, oxygenation, and correction of acidosis and diuresis of critically ill pts with ARDS. FIO₂, inspired O₂ percentage; MAP, mean arterial pressure; PBW, predicted body weight; RR, respiratory rate; SpO₂, arterial oxyhemoglobin saturation measured by pulse oximetry.