Ill or Medicated Individual

1. Drugs

   Insulin or insulin secretagogue

   Alcohol

   Others

2. Critical illness

   Hepatic, renal, or cardiac failure

   Sepsis

   Inanition

3. Hormone deficiency

   Cortisol

   Growth hormone

   Glucagon and epinephrine (in insulin-deficient diabetes)

4. Non-islet cell tumor (e.g., Mesenchymal tumors)

   Seemingly Well Individual

5. Endogenous hyperinsulinism

   Insulinoma

   Functional β-cell disorders (nesidioblastosis)

    Noninsulinoma pancreatogenous hypoglycemia

    Post-gastric bypass hypoglycemia

   Insulin autoimmune hypoglycemia

    Antibody to insulin

    Antibody to insulin receptor

   Insulin secretagogue

   Other

6. Disorders of gluconeogenesis and fatty acid oxidation
7. Exercise
8. Accidental, surreptitious, or malicious hypoglycemia