Common Sources of Infection after Hematopoietic Stem Cell Transplantation | |||
| INFECTION SITE | PERIOD AFTER TRANSPLANTATION | ||
|---|---|---|---|
| EARLY (<1 MONTH) | MIDDLE (1-4 MONTHS) | LATE (>6 MONTHS) | |
| Disseminated | Aerobic bacteria (gram-negative, gram-positive) | Candida, Aspergillus, EBV | Encapsulated bacteria (Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis) |
| Skin and mucous membranes | HSV | HHV-6 | VZV, HPV (warts) |
| Lungs | Aerobic bacteria (gram-negative, gram-positive), Candida, Aspergillus, other molds, HSV | CMV, seasonal respiratory viruses, Pneumocystis, Toxoplasma | Pneumocystis, Nocardia, S. pneumoniae |
| Gastrointestinal tract | Clostridium difficile | CMV, adenovirus | EBV, CMV |
| Kidney | BK virus, adenovirus | ||
| Brain | HHV-6, Toxoplasma | Toxoplasma, JC virus (rare) | |
| Bone marrow | CMV, HHV-6 | CMV, HHV-6 | |