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Table 154-1

Causes of Acute Pancreatitis

Common Causes
Gallstones (including microlithiasis)
Alcohol (acute and chronic alcoholism)
Hypertriglyceridemia
Endoscopic retrograde cholangiopancreatography (ERCP), especially after biliary manometry
Drugs (azathioprine, 6-mercaptopurine, sulfonamides, estrogens, tetracycline, valproic acid, anti-HIV medications, 5-aminosalicylic acid [5-ASA])
Trauma (especially blunt abdominal trauma)
Postoperative (abdominal and nonabdominal operations)
Uncommon Causes
Vascular causes and vasculitis (ischemic-hypoperfusion states after cardiac surgery)
Connective tissue disorders and thrombotic thrombocytopenic purpura (TTP)
Cancer of the pancreas
Hypercalcemia
Periampullary diverticulum
Pancreas divisum
Hereditary pancreatitis
Cystic fibrosis
Renal failure
Infections (mumps, coxsackievirus, cytomegalovirus, echovirus, parasites)
Autoimmune (e.g., type 1 and type 2)
Causes to Consider in Pts with Recurrent Bouts of Acute Pancreatitis without an Obvious Etiology
Occult disease of the biliary tree or pancreatic ducts, especially microlithiasis, biliary sludge
Drugs
Alcohol abuse
Metabolic: Hypertriglyceridemia, hypercalcemia
Anatomic: Pancreas divisum
Pancreatic cancer
Intraductal papillary mucinous neoplasm (IPMN)
Hereditary pancreatitis
Cystic fibrosis
Autoimmune
Idiopathic