Hemodynamic Changes
Orthostatic drop in bp >10 mmHg usually indicates >20% reduction in blood volume (± syncope, light-headedness, nausea, sweating, thirst).
BP <100 mmHg systolic usually indicates <30% reduction in blood volume (± pallor, cool skin).
Laboratory Changes
Hematocrit may not reflect extent of blood loss because of delayed equilibration with extravascular fluid. Mild leukocytosis and thrombocytosis. Elevated blood urea nitrogen is common in upper GI bleeding.
Adverse Prognostic Signs
Age >60 years, associated illnesses, coagulopathy, immunosuppression, presentation with shock, rebleeding, onset of bleeding in hospital, variceal bleeding, endoscopic stigmata of recent bleeding (e.g., visible vessel in ulcer base [see next]).
Section 3. Common Patient Presentations