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Table 186-2

Differential Diagnosis of Parkinsonism

Parkinson's disease

 Sporadic

 Genetic

Dementia with Lewy bodies

Atypical parkinsonism

 Multiple-system atrophy (MSA)

  Cerebellar type (MSA-c)

  Parkinson type (MSA-p)

Progressive supranuclear palsy

  Parkinsonism

  Richardson variant

Corticobasal syndrome

Frontotemporal dementia

Secondary parkinsonism

 Drug-induced

 Tumor

 Infection

 Vascular

 Normal-pressure hydrocephalus

 Trauma

 Liver failure

 Toxins (e.g., carbon monoxide, manganese, MPTP, cyanide, hexane, methanol, carbon disulfide)

Neurodegenerative disorders and other forms of parkinsonism

 Wilson's disease

 Huntington's disease

 Neurodegeneration with brain iron accumulation

 SCA 3 (spinocerebellar ataxia)

 Fragile X-associated ataxia-tremor-parkinsonism

 Prion disease

 X-linked dystonia-parkinsonism

 Alzheimer's disease with parkinsonism

 Dopa-responsive dystonia

Abbreviation: MPTP, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.