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Table 186-2

Differential Diagnosis of Parkinsonism

Parkinson's disease

Sporadic

Genetic

Dementia with Lewy bodies

Atypical parkinsonism

Multiple-system atrophy (MSA)

Cerebellar type (MSA-c)

Parkinson type (MSA-p)

Progressive supranuclear palsy

Parkinsonism

Richardson variant

Corticobasal syndrome

Frontotemporal dementia

Secondary parkinsonism

Drug-induced

Tumor

Infection

Vascular

Normal-pressure hydrocephalus

Trauma

Liver failure

Toxins (e.g., carbon monoxide, manganese, MPTP, cyanide, hexane, methanol, carbon disulfide)

Neurodegenerative disorders and other forms of parkinsonism

Wilson's disease

Huntington's disease

Neurodegeneration with brain iron accumulation

SCA 3 (spinocerebellar ataxia)

Fragile X-associated ataxia-tremor-parkinsonism

Prion disease

X-linked dystonia-parkinsonism

Alzheimer's disease with parkinsonism

Dopa-responsive dystonia

Abbreviation: MPTP, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.