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Table 52-1

Causes of Syncope

A. Neurally Mediated Syncope
 Vasovagal syncope
  Provoked fear, pain, anxiety, intense emotion, sight of blood, unpleasant sights and odors, orthostatic stress
 Situational reflex syncope
  Pulmonary
   Cough syncope, wind instrument player's syncope, weightlifter's syncope, “mess trick”a and “fainting lark,”b sneeze syncope, airway instrumentation
  Urogenital
   Postmicturition syncope, urogenital tract instrumentation, prostatic massage
  Gastrointestinal
   Swallow syncope, glossopharyngeal neuralgia, esophageal stimulation, gastrointestinal tract instrumentation, rectal examination, defecation syncope
  Cardiac
   Bezold-Jarisch reflex, cardiac outflow obstruction
  Carotid sinus
   Carotid sinus sensitivity, carotid sinus massage
  Ocular
   Ocular pressure, ocular examination, ocular surgery
B. Orthostatic Hypotension
 Primary autonomic failure due to idiopathic central and peripheral neurodegenerative diseases-the “synucleinopathies”
  Lewy body diseases
   Parkinson's disease
   Lewy body dementia
   Pure autonomic failure
  Multiple system atrophy (Shy-Drager syndrome)
 Secondary autonomic failure due to autonomic peripheral neuropathies
  Diabetes
  Hereditary amyloidosis (familial amyloid polyneuropathy)
  Primary amyloidosis (AL amyloidosis; immunoglobulin light chain associated)
  Hereditary sensory and autonomic neuropathies (HSAN) (especially type III-familial dysautonomia)
  Idiopathic immune-mediated autonomic neuropathy
  Autoimmune autonomic ganglionopathy
  Sjögren's syndrome
  Paraneoplastic autonomic neuropathy
  HIV neuropathy
 Postprandial hypotension
 Iatrogenic (drug-induced)
 Volume depletion
C. Cardiac Syncope
 Arrhythmias
  Sinus node dysfunction
  Atrioventricular dysfunction
  Supraventricular tachycardias
  Ventricular tachycardias
  Inherited channelopathies
 Cardiac structural disease
  Valvular disease
  Myocardial ischemia
  Obstructive and other cardiomyopathies
  Atrial myxoma
  Pericardial effusions and tamponade

a Hyperventilation for ∼1 min, followed by sudden chest compression.

b Hyperventilation (∼20 breaths) in a squatting position, rapid rise to standing, then Valsalva.