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Table 44-1

Causes of Isolated Hyperbilirubinemia

  • Indirect hyperbilirubinemia
    • Hemolytic disorders
    • Ineffective erythropoiesis
    • Increased bilirubin production
      1. Massive blood transfusion
      2. Resorption of hematoma
    • Drugs
      1. Rifampin
      2. Probenecid
      3. Ribavirin
      4. Protease inhibitors (Atazanavir, Indinavir)
    • Inherited conditions
      1. Crigler-Najjar types I and II
      2. Gilbert's syndrome
  • Direct hyperbilirubinemia (inherited conditions)
    • Dubin-Johnson syndrome
    • Rotor syndrome