Surgery: metastasectomy for small number of lesions

Immunotherapy

 Interleukin-2

Immune checkpoint blockade

• Anti-CTLA-4: ipilimumab
• Anti-PD-1: nivolumab, pembrolizumab
• Combined ipilimumab and nivolumab

Experimental

 Anti-PD-L1

Molecular targeted therapy

 BRAF inhibitor: vemurafenib, dabrafenib

 MEK inhibitor: trametinib, cobimetinib

Oncolytic virus: talimogene laherpaepvec

Chemotherapy: dacarbazine, temozolomide, paclitaxel, albumin-bound paclitaxel, carboplatin