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Table 44-3

Cholestatic Conditions That May Produce Jaundice

  • Intrahepatic
    • Viral hepatitis
      1. Fibrosing cholestatic hepatitis-hepatitis B and C
      2. Hepatitis A, Epstein-Barr virus infection, cytomegalovirus infection
    • Alcoholic hepatitis
    • Drug toxicity
      1. Pure cholestasis-anabolic and contraceptive steroids
      2. Cholestatic hepatitis-chlorpromazine, erythromycin estolate
      3. Chronic cholestasis-chlorpromazine and prochlorperazine
    • Primary biliary cholangitis
    • Primary sclerosing cholangitis
    • Vanishing bile duct syndrome
      1. Chronic rejection of liver transplants
      2. Sarcoidosis
      3. Drugs
    • Congestive hepatopathy and ischemic hepatitis
    • Inherited conditions
      1. Progressive familial intrahepatic cholestasis
      2. Benign recurrent intrahepatic cholestasis
    • Cholestasis of pregnancy
    • Total parenteral nutrition
    • Nonhepatobiliary sepsis
    • Benign postoperative cholestasis
    • Paraneoplastic syndrome
    • Veno-occlusive disease
    • Graft-versus-host disease
    • Infiltrative disease
      1. Tuberculosis
      2. Lymphoma
      3. Amyloidosis
    • Infections
      1. Malaria
      2. Leptospirosis
  • Extrahepatic
    • Malignant
      1. Cholangiocarcinoma
      2. Pancreatic cancer
      3. Gallbladder cancer
      4. Ampullary cancer
      5. Malignant involvement of the porta hepatis lymph nodes
    • Benign
      1. Choledocholithiasis
      2. Postoperative biliary strictures
      3. Primary sclerosing cholangitis
      4. Chronic pancreatitis
      5. AIDS cholangiopathy
      6. Mirizzi's syndrome
      7. Parasitic disease (ascariasis)