IV VASODILATORS AND INOTROPIC DRUGS USED IN ACUTE MI | ||
| DRUG | USUAL DOSAGE RANGE | COMMENT |
|---|---|---|
| Nitroglycerin | 5-100 µg/min | May improve coronary blood flow to ischemic myocardium |
| Nitroprusside | 0.5-10 (µg/kg)/min | More potent vasodilator, but improves coronary blood flow less than nitroglycerin With therapy >24 h or in renal failure, watch for thiocyanate toxicity (blurred vision, tinnitus, delirium) |
| Dobutamine | 2-20 (µg/kg)/min | Results in ↑ cardiac output, ↓ PCW, but does not raise bp |
| Dopamine | 2-20 (µg/kg)/min | More appropriate than dobutamine if hypotensive Hemodynamic effect depends on dose: (µg/kg)/min <5: ↑ renal blood flow 2.5-10: positive inotrope >10: vasoconstriction |
| Norepinephrine | 0.5-30 µg/min | Less likely than dopamine to cause arrhythmias in cardiogenic shock |