Treatment Duration for Nocardiosis

DISEASE	DURATION
Treatment Duration for Nocardiosis
Pulmonary or systemic
Intact host defenses	6-12 months
Deficient host defenses	12 months^a
CNS disease	12 months^b
Cellulitis, lymphocutaneous syndrome	2 months
Osteomyelitis, arthritis, laryngitis, sinusitis	4 months
Actinomycetoma	6-12 months after clinical cure
Keratitis	Topical: until apparent cure Systemic: until 2-4 months after apparent cure

^a In some pts with AIDS and CD4+ T lymphocyte counts of <200/µL or with chronic granulomatous disease, therapy for pulmonary or systemic disease must be continued indefinitely.

^b If all apparent CNS disease has been excised, the duration of therapy may be reduced to 6 months.

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Table 96-1