Antibodies to Intracellular Antigens, Syndromes, and Associated Cancers | ||
| ANTIBODY | ASSOCIATED NEUROLOGIC SYNDROME(S) | TUMORS |
|---|---|---|
| Anti-Hu (ANNA1) | Encephalomyelitis, subacute sensory neuronopathy | SCLC |
| Anti-Yo (PCA1) | Cerebellar degeneration | Ovary, breast |
| Anti-Ri (ANNA2) | Cerebellar degeneration, opsoclonus, brainstem encephalitis | Breast, gynecologic, SCLC |
| Anti-CRMP5 (CV2) | Encephalomyelitis, chorea, optic neuritis, uveitis, peripheral neuropathy | SCLC, thymoma, other |
| Anti-Ma proteins | Limbic, hypothalamic, brainstem encephalitis | Testicular (Ma2), other (Ma) |
| Anti-amphiphysina | Stiff-person syndrome, encephalomyelitis | Breast, SCLC |
| Recoverin, bipolar cell antibodies, othersb | Cancer-associated retinopathy (CAR) Melanoma-associated retinopathy (MAR) | SCLC (CAR), melanoma (MAR) |
| Anti-GAD | Stiff-person, cerebellar syndrome, limbic encephalitis | Infrequent tumor association (thymoma and several cancers) |
a Amphiphysin is likely exposed to the cell surface during synaptic vesicle endocytosis. b A variety of target antigens have been identified.
Abbreviations: CRMP, collapsing response-mediator protein; SCLC, small-cell lung cancer.