Haemophilus spp.

Aggregatibacter spp.

Cardiobacterium spp.

Eikenella corrodens

Kingella kingae

Ceftriaxone (2 g/d)

Ampicillin/sulbactam (3 g of ampicillin q6h)

Levofloxacin (750 mg/d)

Ampicillin/sulbactam resistance has been described in Haemophilus and Aggregatibacter spp.

Data on use of levofloxacin for endocarditis therapy are limited. Fluoroquinolones are not recommended for treatment of pts <18 years of age.

Penicillin (16-18 million units q4h) or ampicillin (2 g q4h) can be used if the organism is susceptible. However, because of the slow growth of HACEK bacteria, antimicrobial testing may be difficult, and β-lactamase production may not be detected.