The Physiologic Classification of Anemia

The Physiologic Classification of Anemia - Flowchart

«Flowchart»

ALGORITHM OF THE PHYSIOLOGIC CLASSIFICATION OF ANEMIA

Anemia

ALGORITHM OF THE PHYSIOLOGIC CLASSIFICATION OF ANEMIA

Anemia

ALGORITHM OF THE PHYSIOLOGIC CLASSIFICATION OF ANEMIA

Anemia

End

CBC, complete blood count.

CBC, reticulocyte count

Index <2.5

Index 2.5

Index >=2.5

Red cell morphology

Normocytic normochromic

Micro or macrocytic

Hypoproliferative

Marrow damage

Infiltration/fibrosis
Aplasia

Marrow damage

Infiltration/fibrosis
Aplasia

Infiltration/fibrosis
Aplasia Marrow damage

Iron deficiency

Stimulation

Inflammation
Metabolic defect
Renal disease

Stimulation

Inflammation
Metabolic defect
Renal disease

Inflammation
Metabolic defect
Renal disease Decrease Stimulation

Maturation disorder

Cytoplasmic defects

Iron deficiency
Thalassemia
Sideroblastic anemia

Cytoplasmic defects

Iron deficiency
Thalassemia
Sideroblastic anemia

Iron deficiency
Thalassemia
Sideroblastic anemia Cytoplasmic defects

Nuclear defects

Folate deficiency
Vitamin B₁₂ deficiency
Drug toxicity
Myelodysplasia

Nuclear defects

Folate deficiency
Vitamin B₁₂ deficiency
Drug toxicity
Myelodysplasia

Folate deficiency
Vitamin B₁₂ deficiency ₁₂
Drug toxicity
Myelodysplasia Nuclear defects

Hemolysis/hemorrhage

Blood loss

Intravascular hemolysis

Metabolic defect

Membrane abnormality

Hemoglobinopathy

Immune destruction

Fragmentation hemolysis