Multiple myeloma criteria
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Major Diagnostic Criteria
☐Plasmacytoma on tissue biopsy
☐Bone marrow plasmacytosis of >30%
☐M Protein (IgG>3.5 g/dL; IgA>2.0 g/dL)
☐Urinary kappa or lambda chain excretion of >1g/24 hours (Amyloidosis must be absent)
Minor Diagnostic Criteria
☐Marrow plasmacytosis of 10-30%
☐Lytic bone lesions
☐Monoclonal protein present (But in lesser amounts than required in major criteria)
☐Hypoglobulinemia of normal proteins (IgM<500 mg/L, IgA<1 g/L or IgG<6 g/L)
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Multiple myeloma criteria

Multiple myeloma is a cancer of plasma cells and is a progressive hematologic disease that currently has no cure, but is treatable. Incidence is 5-6/100,000/year with a male and African American predominance. Age is a major risk factor, with just 1% of cases occurring under age 40 years and the average age at diagnosis being 68 years.

The diagnostic criteria of Durie and Salmon require either:

  • 1 Major Criteria and 1 Minor Criteria
  • 0 Major Criteria and 3 Minor Criteria

Major Diagnostic Criteria

  • Plasmacytoma on tissue biopsy
  • Bone marrow plasmacytosis of >30%
  • M Protein (IgG >3.5 g/dL; IgA >2.0 g/dL)
  • Urinary kappa or lambda chain excretion of >1g/24 hours (Amyloidosis must be absent)

Minor Diagnostic Criteria

  • Marrow plasmacytosis of 10-30%
  • Lytic bone lesions
  • Monoclonal protein present (But in lesser amounts than required in major criteria)
  • Hypoglobulinemia of normal proteins (IgM <500 mg/L, IgA <1 g/L or IgG <6 g/L)

References:

  • Durie BG, Salmon SE. A clinical staging system for multiple myeloma. Cancer. 1975;36:842-854.