Formerly known as “phacoanaphylaxis,” this rare condition presents with chronic granulomatous uveitis in response to prior sensitization of lens material liberated by trauma or intraocular surgery. It may have associated glaucomatous optic neuropathy, although this is rare at presentation. After lens material is liberated, there is a latent period where an immune sensitivity develops. Inflammatory cells surround lens material, and glaucoma may result from blockage of the TM by these cells and lens particles. Other forms of uveitis should be considered, including sympathetic ophthalmia. Other forms of lens-induced glaucoma must be considered including lens particle and phacolytic glaucoma. Treatment is with topical steroids and antiglaucoma medications. The lens should be removed surgically, particularly if IOP or inflammation cannot be adequately controlled with medications.