Causes of male hypogonadism. | |
| Hypogonadotropic (Low or Normal LH) | Hypergonadotropic (High LH) |
|---|---|
Aging Alcohol Chronic illness Constitutional delay of growth and puberty Cushing syndrome Drugs Estrogen GnRH agonist (leuprolide) Ketoconazole Marijuana Opioids (oral, injected, or intrathecal) Prior androgens Spironolactone Genetic conditions1 Granulomatous diseases Hemochromatosis Hypopituitarism Hypothalamic or pituitary tumors Hypo-, hyperthyroidism Idiopathic Kidney disease Lymphocytic hypophysitis Major medical or surgical illnesses Malnourishment Obesity (BMI >30) | Aging Autoimmunity Anorchia (bilateral) Chemotherapy Idiopathic Klinefelter syndrome Leprosy Lymphoma Male climacteric Myotonic dystrophy Noonan syndrome Orchiectomy (bilateral or unilateral) Orchitis Radiation or radioisotope therapy Sertoli cell-only syndrome Testicular trauma Tuberculosis Uremia Viral infections (mumps) XY gonadal dysgenesis |