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Table 28-12

Multiple endocrine neoplasia (MEN) syndromes: incidence of tumor types.

Tumor TypeMEN 1MEN 2 (MEN 2A)MEN 3 (MEN 2B)MEN 4
Parathyroid95%20-50%RareCommon
Pancreatic54% Common
Pituitary42% Common
Medullary thyroid carcinoma >90%80%
PheochromocytomaRare20-35%60%
Mucosal and GI ganglioneuromas Rare>90%
Subcutaneous lipoma30%
Adrenocortical adenoma30% Common
Thoracic carcinoid15%
Thyroid adenoma55% Common
Facial angiofibromas and collagenomas85%
Breast cancer27%