| Dosage | |
|---|---|
| Older Agents | |
| Tricyclic Antidepressants (TCAs) and their derivatives | |
| Imipramine (Tofranil) | 50–300 mg/day |
| Amitriptyline (Elavil) | 50–300 mg/day |
| Clomipramine (Anafranil) | 50–250 mg/day |
| Doxepin (Sinequan) | 25–300 mg/day |
| Amoxapine (Ascendin) | 50–300 mg/day |
| Desipramine (Norpramin) | 50–300 mg/day |
| Nortriptyline (Pamelor/Aventyl) | 25–150 mg/day |
| Monoamine Oxidase Inhibitors (MAOIs) | |
| Phenelzine (Nardil) | 15–90 mg/day |
| Tranylcypromine (Parnate) | 10–60 mg/day |
| Selegiline transdermal patch (EMSAM) | 6–12 mg/day |
| Newer Agents | |
| Selective Serotonin Reuptake Inhibitors (SSRIs) | |
| Fluoxetine (Prozac) | 20–80 mg/day |
| Fluvoxamine (Luvox) | 50–300 mg/day |
| Paroxetine (Paxil) | 10–60 mg/day |
| Sertraline (Zoloft) | 50–200 mg/day |
| Citalopram (Celexa) | 20–60 mg/day |
| Escitalopram (Lexapro) | 10–20 mg/day |
| Non-SSRIs | |
| Serotonin and Norepinephrine Reuptake Inhibitor (SNRI) | |
| Venlafaxine (Effexor) | 75–375 mg/day |
| Duloxetine (Cymbalta) | 40–60 mg/day |
| Serotonin 2A Blocker | |
| Nefazodone (Serazone) | 50–600 mg/day |
| Trazodone (Desyrel) | 200–600 mg/day |
| Serotonin 2A/C and Norepinephrine (alpha-2) Blocker | |
| Mirtazapine (Remeron) | 15–45 mg/day |
| Dopamine and Norepinephrine Reuptake Inhibitor | |
| Bupropion (Wellbutrin, Zyban) | 75–450 mg/day |