Possible Side Effects and Toxic Effects of Lithium

• Initial adjustment period of several weeks: Increased thirst, dry mouth, increased urination, mild nausea, worsening of acne or psoriasis, metallic taste, weight gain, occasional loose stools, mild dizziness, decreased sexual desire, slight muscular weakness, sleepiness, fine tremor in hands, mild stomach cramps.
• Long-term: Hypothyroidism with swelling of the gland, sleepiness, feeling cold, unusual weight gain, headache, tiredness, cold fingers and toes, menstrual changes, dry puffy skin, constipation, muscle aches, slow thinking.
• Toxic effect from elevated blood level: Persistent diarrhea, vomiting, coarse trembling of hands or legs, frequent muscle twitching in the arms or legs, blurred vision, confusion, severe discomfort, weakness, severe dizziness, seizure, coma, death.