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Basics

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BASICS

Overview!!navigator!!

  • Caused by lesions within the respiratory tract but can be secondary to hemostatic dysfunctions (rare)
  • Unilateral discharge—often lesions rostral to the nasopharynx
  • Bilateral discharge—often lesions caudal to the nasopharynx or from hemostatic dysfunctions
  • Systems affected—respiratory and hemic

Signs!!navigator!!

  • Blood trickle at the nostril(s) to severe hemorrhage
  • Unilateral trickle; upper respiratory origin; nasal passage, turbinates, or paranasal sinuses. Sometimes ipsilateral guttural pouch hemorrhage
  • Bilateral trickle or severe hemorrhage; origin caudal to the nasopharynx (guttural pouch, lower respiratory tract) or hemostatic disorders
  • Mucopurulent or foul-smelling discharges suggest an infectious or necrotic origin
  • Bilateral frothy discharge is consistent with pulmonary edema
  • Thrombocytopenia and DIC often are associated with mucosal petechiation, prolonged bleeding from venipuncture sites, and occult blood from the GI or urinary tracts

Causes and Risk Factors!!navigator!!

  • Hemostatic dysfunction—thrombocytopenia, DIC, coagulation factor deficiency, or envenomation
  • Respiratory tract disease—upper respiratory disease may result from primary bacterial or fungal infections (guttural pouch mycosis, sinusitis), neoplasia or idiopathic diseases (nasal polyp, nasal amyloidosis, ethmoid hematoma). Lower respiratory diseases include EIPH, pleuropneumonia, pulmonary edema, lung neoplasia
  • Trauma—nasal intubation, fractures, longus capitis muscle rupture secondary to falling backward, and lung biopsy
  • Other—vasculitis (purpura haemorrhagica), fibrous dysplasia, periocular bleeding

Diagnosis

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DIAGNOSIS

CBC/Biochemistry/Urinalysis!!navigator!!

  • Usually within normal range, however anemia may result from blood loss
  • Neutrophilia or neutropenia may accompany inflammatory diseases
  • Leukemia may be evident with myeloid neoplasia

Other Laboratory Tests!!navigator!!

Assessment of hemostasis requires platelet count, plasma fibrinogen, prothrombin and activated partial thromboplastin time, and d-dimer concentration.

Imaging!!navigator!!

  • Skull radiography may reveal bone fracture, mass, or fluid accumulation in the sinuses or guttural pouches
  • Thoracic radiography may help to identify pleuropneumonia, EIPH, pulmonary edema, and lung tumors
  • Thoracic ultrasonography is sensitive to detect pleural blood or effusion

Other Diagnostic Procedures!!navigator!!

  • Endoscopy of the respiratory tract is helpful to identify the site of bleeding; nasal passages, pharynx, guttural pouches (needs a stylet), and lower airways examination
  • Trephination to access paranasal sinuses using a flexible or rigid endoscope
  • Fluid cytology from bronchoalveolar lavage (for EIPH) or thoracocentesis may reveal the source of bleeding
  • Biopsy to identify the nature of a mass

Pathologic Findings!!navigator!!

  • Depend on the primary disease process
  • Nasal and paranasal neoplasms are malignant in 68% of cases

Treatment

TREATMENT

  • Emergency if severe bleeding or guttural pouch hemorrhage is suspected
  • Treat the primary disease
  • Stall rest is recommended and sedation if horse is agitated
  • Treat severe blood loss with IV administration of sodium-containing crystalloid solutions. However, if the hemorrhage is not controlled, volume expansion may worsen blood loss. Perform blood transfusion when the red blood cell mass is insufficient to maintain tissue oxygenation (e.g. >30% blood volume lost acutely)
  • Patients with hemostatic disorders may benefit from fresh plasma transfusion
  • Consider surgical or laser resection of a nasal or paranasal mass
  • Guttural pouch mycosis may be treated surgically by occlusion of the affected artery

Medications

MEDICATIONS

Drug(s) of Choice

  • Immunosuppressive therapy with corticoids (dexamethasone 0.05–0.2 mg/kg IM or IV every 24 h) in cases of immune-mediated coagulopathy or vasculitis
  • Heparin (20–80 IU/kg SC or IV every 6–12 h) and low-dose aspirin (15 mg/kg PO every 24–48 h) may reduce complications of DIC
  • Warfarin and sweet clover toxicosis—treat with vitamin K1 (0.5–1 mg/kg SC every 6 h)
  • Antifibrinolytics may help decrease blood loss (aminocaproic acid 10–20 mg/kg IV)
  • Pulmonary edema—treat with furosemide (1 mg/kg IV) and respiratory support

Follow-up

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FOLLOW-UP

Patient Monitoring!!navigator!!

Monitor hematocrit and hydration status.

Possible Complications!!navigator!!

Severe, fatal bleeding may occur if a major artery is involved.

Expected Course and Prognosis!!navigator!!

Depend on the underlying cause.

Miscellaneous

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MISCELLANEOUS

Abbreviations!!navigator!!

  • DIC = disseminated intravascular coagulation
  • EIPH = exercise-induced pulmonary hemorrhage
  • GI = gastrointestinal

Suggested Reading

Collatos C. Blood loss anemia. In: Robinson NE, ed. Current Therapy in Equine Medicine, 5e. Philadelphia, PA: WB Saunders, 2003:340342.

Author(s)

Author: Renaud Leguillette

Consulting Editors: Daniel Jean and Mathilde Leclère

Acknowledgment: The author and editors acknowledge the prior contribution of Laurent Couëtil.