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Basics

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BASICS

Definition!!navigator!!

  • Chronic colic originating usually, but not exclusively, from the GI tract and that has been present constantly or intermittently for >3 days. It may also originate from other abdominal organs such as liver, spleen, kidney, uterus, and peritoneum
  • Chronic abdominal pain refers to continuous or intermittent signs of abdominal pain of >3 days’ duration
  • Recurrent abdominal pain refers to several episodes of transient or prolonged abdominal pain separated by a period of a few days or weeks in which the horse is usually normal

Pathophysiology!!navigator!!

Pain from within the intestinal tract may result from intramural tension, tension on a mesentery, inflammation, spasm associated with hypermotility, or a combination of those. Most cases of chronic colic usually exclude strangulating obstructive events.

Systems Affected!!navigator!!

  • GI
  • Cardiovascular—may be affected as a result of progressive dehydration, toxemia
  • Other systems such as urinary, reproductive, or hepatic may be involved

Signalment!!navigator!!

Non-specific. Previous abdominal surgery results in a risk of adhesions leading to chronic colic.

Signs!!navigator!!

General Comments

Signs of abdominal pain are usually mild to moderate.

Historical Findings

  • There may be a recent history of change in diet or exercise regimen, lack of access to drinking water, deworming, weight loss, previous infection, or abdominal surgery
  • A change in attitude (depression), appetite, and fecal output may be noticed

Physical Examination Findings

Vital signs are usually normal to moderately affected. The following signs might be observed:

  • General findings—none to moderate abdominal distention; weight loss
  • Cardiovascular findings—normal to mild changes in color of the mucous membrane, increase in capillary refill time, normal to moderate increase in heart rate, and dehydration may occur with time. May have signs of endotoxemia such as hyperemic mucous membranes and increase in heart rate
  • GI findings—normal, decreased, or increased gut motility; abnormal sounds may be heard in sand impactions; may have a gas-filled viscus on percussion; may have presence of gastric reflux on passage of the nasogastric tube. Feces are normal, reduced, or absent, or there may be diarrhea
  • Abnormalities on rectal examination—distention of a viscus by gas, liquid, or food; displacement of a viscus; abnormal intestinal diameter or wall thickness; uterine or renal abnormalities; palpation of a mass. May have a painful response on palpation of a specific area

Causes!!navigator!!

The most common cause of chronic colic located at the GI level is large colon impaction, but there are others causes, such as chronic peritonitis, enteritis/colitis, colonic displacement, parasite infestation, ulceration, and intussusception. For recurrent abdominal pain, the most common cause is spasmodic colic but also includes processes such as chronic ulceration, non-total disturbance of the intestinal lumen due to adhesions, stricture, intussusception, enteroliths, intra-abdominal masses such as abscesses and neoplasms, and sand impactions.

GI

  • Gastric—gastric ulcer, gastric neoplasia
  • Small intestine—duodenal ulcer, duodenojejunal enteritis, chronic inflammatory bowel disease, adhesions, stricture, intussusception, neoplasia, impaction, muscular hypertrophy, etc.
  • Large intestine, cecum, and small colon—impaction, adhesions, ulceration, spasmodic colic, enteroliths, fecalith, sand impaction, neoplasia, chronic inflammatory bowel disease, displacement

Reproductive

  • Ovarian tumor
  • Uterine torsion
  • Late stage of pregnancy

Renal/Urologic

  • Renal/ureteral/bladder/urethral calculi
  • Pyelonephritis
  • Cystitis
  • Renal inflammatory process

Hepatobiliary

  • Hepatitis
  • Hepatobiliary calculi
  • Abscesses

Other Systems Affected

  • Peritonitis
  • Mesenteric abscesses
  • Abdominal neoplasia (e.g. lymphosarcoma)

Risk Factors!!navigator!!

Previous surgery, diet, environment, excessive use of NSAIDs, Anoplocephala infestation, larval cyathostomiasis, strongylosis, no access to water, sudden change in exercise, history of deworming, pregnancy. Horses with severe dental disease may fail to masticate coarse herbage and be prone to impactions.

Diagnosis

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DIAGNOSIS

Differential Diagnosis!!navigator!!

Other causes of pain that might resemble pain originating from the abdominal cavity include myositis, pleuropneumonia, and neurologic and musculoskeletal injury.

CBC/Biochemistry/Urinalysis!!navigator!!

  • Packed cell volume and total protein might be increased due to dehydration
  • Hypoproteinemia is seen in conditions such as chronic ulceration, intussusception, neoplasia, parasitism, infectious disease, and chronic inflammatory bowel disease. Total globulin concentration may be increased in chronic inflammatory processes and strongyle parasitism
  • The fibrinogen concentration is increased in the presence of inflammation
  • Leukocytosis in chronic inflammatory processes
  • Anemia may result from chronic inflammatory processes or chronic bleeding
  • Hypochloremia, hyponatremia, and low bicarbonate concentrations seen in colitis
  • Presence of azotemia occurs in severely dehydrated horses or in cases of renal disease. Liver enzymes may also be increased if hepatic disease is present

Other Laboratory Tests!!navigator!!

  • Abdominal paracentesis—cytology of the abdominal fluid may be normal or may reveal the presence of an inflammatory process. The presence of abnormal or mitotic cells may suggest lymphosarcoma. Bacteriology of abdominal fluid in cases of peritonitis may be helpful in isolating an agent and appropriately choosing antibiotic therapy
  • Melena in feces—ulcerative disease, intussusceptions of the small intestine
  • Fecal analysis for the presence of parasite eggs and sand
  • Fecal bacteriology might help to identify the cause of inflammatory abdominal pain (Salmonella spp., Clostridia spp.)
  • Urinalysis—change in specific gravity or an increase in leukocyte content, red blood cells, and pH may be noticed if renal disease is present

Imaging!!navigator!!

  • Radiographs—may be useful in identification of sand impaction or enteroliths
  • Ultrasonography—evaluation of abdominal fluid, wall thickness and diameter of small intestine, nephrosplenic space, and motility and wall thickness of the large intestine; and abnormal findings such as intussusception, abscess, or adhesions. Also useful in evaluating the kidneys, liver, spleen, and uterus
  • Gastroscopy—evaluation of the glandular and nonglandular part of the stomach for ulcer or impaction
  • Cystoscopy—evaluation of the urethra, bladder, and opening of the ureters for inflammation, urolithiasis
  • Laparoscopy—visualization of abdominal viscera

Other Diagnostic Procedures!!navigator!!

  • Biopsy—intestinal, liver, or renal biopsy for histology
  • Histology—biopsy of kidney or liver if these are suspected to be the origin of the problem; intestinal biopsy
  • Exploratory laparotomy or laparoscopy—to identify the origin of the problem if it has not been determined by other tests

Treatment

TREATMENT

The treatment depends on the source of the problem. The treatment may be supportive or curative, medical, or surgical. Moderate or severe cases of cecal impaction are an indication to perform exploratory laparotomy to prevent cecal rupture.

Medications

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MEDICATIONS

Drug(s) of Choice!!navigator!!

Analgesics

Analgesics control the abdominal pain, and include:

  • NSAIDs—flunixin meglumine, dipyrone (metamizole), ketoprofen
  • α2-Blockers, such as xylazine, detomidine, or romifidine, can also be given in more severe cases
  • Although usually not needed unless signs of pain are severe, narcotic analgesics such as butorphanol can be given alone or in conjunction with an α2-blocker

Spasmolytics

N-butylscopolammonium bromide (hyoscine butylbromide; Buscopan).

Laxatives

To soften ingesta; mainly used for impaction:

  • Mineral oil—10 mL/kg via nasogastric tube
  • Osmotic laxative—diluted magnesium sulfate in 4 L warm water via nasogastric tube
  • Dioctyl sodium succinate (docusate sodium)
  • IV balanced electrolytes solution

Fluids

  • Parenteral—in cases of dehydration or moderate to severe impaction, IV fluid therapy should be initiated with a balanced electrolyte solution (lactated Ringer's solution). Unbalanced electrolytes should be corrected, especially hypokalemia and hypocalcemia, which are important for intestinal motility
  • Orally—in cases of impaction where good GI motility is present, 5 L of water every 2 h can be given by nasogastric tube (check for gastric reflux prior to giving water)

Antibiotic Therapy

Antibiotic therapy should be started if peritonitis or infectious disease is suspected, or if surgery is performed. Usually, broad-spectrum antibiotics such as a combination of penicillin (20 000 IU/kg IV QID) and gentamicin (6.6 mg/kg IV SID) or trimethoprim–sulfamethoxazole (30 mg/kg IV BID) are given. Surgical exploration may be necessary to determine the cause of chronic or recurrent signs of abdominal discomfort.

Precautions!!navigator!!

  • Repeated use of α2-blockers and butorphanol may cause ileus
  • Repeat doses of NSAIDs, especially in cases of dehydration, can result in gastric or large colon ulceration as well as renal damage

Possible Interactions!!navigator!!

N/A

Alternative Drugs!!navigator!!

N/A

Follow-up

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FOLLOW-UP

Patient Monitoring!!navigator!!

The heart rate and cardiovascular status of the horse should be monitored closely to detect any deterioration.

Possible Complications!!navigator!!

Chronic signs of pain nonresponsive to medical treatment, intestinal rupture secondary to intestinal necrosis due to an enterolith, and severe impaction are indications for an exploratory laparotomy.

Miscellaneous

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MISCELLANEOUS

Zoonotic Potential!!navigator!!

N/A

Pregnancy/Fertility/Breeding!!navigator!!

Late stage of pregnancy can result in intermittent mild signs of abdominal discomfort.

Synonyms!!navigator!!

Chronic/recurrent colic

Abbreviations!!navigator!!

  • GI = gastrointestinal
  • NSAID = nonsteroidal anti-inflammatory drug

Suggested Reading

Hackett ES. Specific causes of colic. In: Southwood LL, ed. Practical Guide to Equine Colic. Ames, IA: Wiley Blackwell, 2013:204230.

Hillyer MH, Mair TS. Chronic colic in the mature horse: a retrospective review of 106 cases. Equine Vet J 1997:29:415420.

Hillyer MH, Mair TS. Recurrent colic in the mature horse: a retrospective review of 58 cases. Equine Vet J 1997;29:421424.

Mair T, Divers T, Ducharme N. Manual of Equine Gastroenterology. Philadelphia, PA: WB Saunders, 2002:101141.

Mair T, Divers T, Ducharme N. Manual of Equine Gastroenterology. Philadelphia, PA: WB Saunders, 2002:427442.

Southwood LL. Gastrointestinal parasitology and anthelmintics. In: Southwood LL, ed. Practical Guide to Equine Colic. Ames, IA: Wiley Blackwell, 2013:316324.

Author(s)

Author: Nathalie Coté

Consulting Editor: Henry Stämpfli and Olimpo Oliver-Espinosa