IA corticosteroids and sodium hyaluronate combination.
Systemic chondroprotective drugspolysulfated glycosaminoglycan (500 mg IM every 4 days for 7 treatments) or sodium hyaluronate (40 mg IV every 7 days for 3 treatments).
Oral chondroprotective medicationsglucosamine/chondroitin sulfate powder (1 scoop (3.3 g) every 12 h), bisphosphonate (Osphos; clodronate (clodronic acid) injection) (60 mg/mL, 15 mL IM divided into 2 sites; ± repeated >6 months)
Contraindications/Possible Interactions
IA corticosteroids not recommended with previous laminitis.
±Mild abdominal discomfort <30 min after clodronate