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Basics

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BASICS

Definition!!navigator!!

  • A rare metabolic condition resulting from hypocalcemia in heavily lactating mares.
  • Clinical signs are progressive and include muscle fasciculations; stiff, stilted gait; tachycardia with dysrhythmias

Pathophysiology!!navigator!!

  • Loss of calcium in the milk, mainly in heavily milking mares kept on lush pasture.
  • Also in well-muscled mares that are working while lactating, in lactating mares that are transported over long distances, or in mares 1–2 days post weaning

Systems Affected!!navigator!!

  • Mammary.
  • Musculoskeletal.
  • Cardiovascular

Genetics!!navigator!!

Draft breeds—Belgian, Percheron, Clydesdale, but not exclusively.

Incidence/Prevalence!!navigator!!

Rare

Signalment!!navigator!!

  • See Pathophysiology.
  • Draft mares.
  • No age predisposition.
  • Unlikely occurrence in primiparous mares

Signs!!navigator!!

  • Related to the level of serum calcium.
  • May include:
    • Muscle fasciculations of the temporal, masseter, and triceps muscles.
    • Generalized increased muscle tone; stiff, stilted gait; rear limb ataxia.
    • Trismus; dysphagia; salivation.
    • Profuse sweating; elevated rectal temperature; anxiety; tachycardia with dysrhythmias.
    • Synchronous diaphragmatic flutter, convulsions, coma, and death.
    • If untreated, the condition is progressive over a 24–48 h period.
    • Increased excitability with calcium levels that are below normal (normal range 11–13 mg/dL) but >8 mg/dL.
    • Calcium levels of 5–8 mg/dL usually produce signs of tetanic spasms and incoordination.
    • Serum calcium levels <5 mg/dL—often become stuporous and are recumbent

Causes!!navigator!!

Loss of calcium in milk.

Risk Factors!!navigator!!

Lactation, postpartum, heavier milking mares, exercise, transport, weaning or other stressful events.

Diagnosis

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DIAGNOSIS

Total serum calcium values <8 mg/dL, coupled with associated clinical signs.

Differential Diagnosis!!navigator!!

  • Colic.
  • Laminitis.
  • Myositis.
  • Tetanus.
  • Other neuromuscular disorders

CBC/Biochemistry/Urinalysis!!navigator!!

  • Hyper-/hypophosphatemia and hyper-/hypomagnesemia may also be present.
  • Hypomagnesemia/hypocalcemia with transport of heavily lactating mares

Diagnostic Procedures!!navigator!!

  • No clinical signs if ionized calcium is within normal range. Normal ionized calcium is possible despite hypocalcemia, if a mare is severely hypoproteinemic.
  • There may be excess protein in the mare's urine

Pathologic Findings!!navigator!!

None

Treatment

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TREATMENT

Appropriate Health Care!!navigator!!

Therapy is recommended in nearly all cases. A few mildly affected cases will recover without treatment.

Nursing Care!!navigator!!

Occasionally, a mare may require a second calcium treatment, if relapse occurs.

Activity!!navigator!!

Restrict transit of heavily lactating mares during the susceptible period, the first 10–12 days postpartum.

Diet!!navigator!!

  • Restrict access of heavily lactating mares to lush pasture if they have a history of eclampsia.
  • Feed high-protein, high-calcium diets post foaling for mares with a history of eclampsia

Client Education!!navigator!!

Reduce nutritional intake (quality) in heavily lactating mares for 1–2 weeks prior to weaning to reduce milk production.

Medications

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MEDICATIONS

Drug(s) of Choice!!navigator!!

  • IV calcium, in the form of 20% calcium borogluconate or 23% calcium gluconate.
  • Rate—250–500 mL per 500 kg body weight.
  • Calcium solutions should be diluted 1:4 with saline or dextrose

Precautions!!navigator!!

  • Use caution when administering calcium solutions due to potential cardiotoxic effects.
  • Imperative to monitor the heart for any alterations in rate or rhythm. If alterations occur, the treatment should immediately be stopped.
  • Dilution of the calcium with saline or dextrose reduces the potential for cardiotoxic effects

Follow-up

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FOLLOW-UP

Patient Monitoring!!navigator!!

  • A reduction in the clinical signs and a positive inotropic effect indicate treatment is effective.
  • If no response is evident after the initial treatment, a second treatment may be necessary in 30 min

Prevention/Avoidance!!navigator!!

  • Decreasing high-protein feeds in the mare's diet late in gestation may decrease incidence in susceptible mares.
  • In previously affected mares, decrease intake of calcium 2–5 weeks before foaling.
  • High-protein, high-calcium diets after foaling for mares prone to eclampsia.
  • See Diet and Client Education for susceptible mares

Possible Complications!!navigator!!

Cardiovascular effects.

Expected Course and Prognosis!!navigator!!

  • Most mares respond to treatment with a full recovery; however, relapses can occur, necessitating additional therapy.
  • Recurrence possible if no changes in the management conditions

Miscellaneous

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MISCELLANEOUS

Pregnancy/Fertility/Breeding!!navigator!!

Occurs either late in gestation or during the peripartum period.

Synonyms!!navigator!!

  • Lactation tetany.
  • Puerperal tetany.
  • Transit tetany

See Also!!navigator!!

Dystocia

Suggested Reading

Baird JD. Lactation tetany (eclampsia) in a Shetland Pony mare. Aust Vet J 1971;47:402404.

Fenger CK. Disorders of calcium metabolism. In: Reed SM, Bayly WM, eds. Equine Internal Medicine. Philadelphia, PA: WB Saunders Co., 1998:930931.

Valberg SJ, Hodgson DR. Diseases of muscle. In: Smith BP, ed. Large Animal Internal Medicine, 2e. St. Louis, MO: Mosby, 1996:14981499.

Author(s)

Author: Carla L. Carleton

Consulting Editor: Carla L. Carleton