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Table 28-1

FormulationCharacteristicsAdvantagesDisadvantages
OintmentsOil-based. Provide occlusive film over skin and help retain water. Aid skin hydration and penetration of topical treatmentTend not to require preservatives as lack of water in preparation prevents microbial growthGreasy and cosmetically less appealing to use
CreamsEmulsions containing water and oil. May be composed of oil in water or water in oil (oily creams). Aid skin hydration, but generally less effectively than ointmentsCosmetically acceptableContain preservatives, which may cause sensitisation
LotionsWatery suspensions, often containing alcohol

Easily spread over a large area. Evaporation of water or alcohol has a drying, cooling effect

Cosmetically acceptable

Useful for hair-bearing areas, such as the scalp

Contain preservatives and therefore have sensitising potential. Alcohol may cause stinging
Gels

Semisolid emulsion in alcohol base. Useful for suspending insoluble drugs

Good absorbent properties

Tend to dry on skin

Useful for hair-bearing areas. Cosmetically acceptable especially for use on the face

Relatively high irritant and sensitising potential