| Box 16-3 | Recommended Administration Set Change Schedule |
| Type of Infusion/Type of Device | Recommended Frequency |
|---|---|
| Change if the integrity of the product or system has been compromised | |
| Intermittent administration sets | Every 24 hours |
| Administration sets with inline or add-on filters used to administer PN | Change every 24 hours or with each new PN container. |
| Administration sets used to administer IV lipid emulsions (ILE) | Change every 12 hours and/or with each new ILE container. |
| Administration sets used to administer blood and blood components | If the first unit of blood requires 4 hours for transfusion, do not reuse toe administration set or filter. Most standard filters have a 4-unit maximum capacity for reuse. |
| Change if the integrity of the product or system has been compromised | |
| Intermittent administration sets | Every 24 hours |
Source: Adapted from Gorski, L. A., Hadaway, L., Hagle, M. E., Broadhurst, D., Clare, S., Kleidon, T., Meyer, B. M., Nickel, B., Rowley, S., Sharpe, E., & Alexander, M.; Infusion Nurses Society. (2021). Infusion therapy. Standards of practice, 8th edition. Journal of Infusion Nursing, 44(Suppl 1), S1-S224. https://doi.org/10.1097/NAN.0000000000000396