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Information

Acetadote is the only FDA-approved IV formulation of acetylcysteine (Mucomyst), developed specifically for use after ingestion of a hepatotoxic dose of acetaminophen.

Dosage (For patients that weigh >40 kg)

  • Load: 150 mg/kg in 200 mL D5W, infuse over 1 hour
  • Maintenance: 50 mg/kg in 500 mL D5W over 4 hours, followed by 100 mg/kg in 1 L D5W over 16 hours

Considerations

  • Serum sample should be drawn at least 4 hours after ingestion.
  • Drug should be administered within 8 hours of ingestion for maximal protection against hepatic injury.
  • If time of ingestion is unknown, or if the concentration level cannot be obtained or is unable to be interpreted within 8 hours of known ingestion, acetadote should be administered immediately, regardless of the quanity reported to have been ingested.