Rifampin is available as a lyophilized powder in vials containing rifampin 600 mg, sodium formaldehyde sulfoxylate 10 mg, and sodium hydroxide to adjust the pH.3919; 3920 Reconstitute each vial with 10 mL of sterile water for injection to yield a solution containing rifampin 60 mg/mL; swirl gently to dissolve the vial contents.3919
Trade Name(s)
Rifadin I.V.
Rifampin is administered by intravenous infusion.3919 It must not be administered intramuscularly or subcutaneously, and extravasation should be avoided.3919 Following reconstitution, the dose may be diluted in 500 mL of dextrose 5% or sodium chloride 0.9% and infused over 3 hours.3919 Alternatively, the dose may be diluted in 100 mL and administered over 30 minutes.3919 Solutions other than dextrose 5% or sodium chloride 0.9% are not recommended.3919; 3920
Rifampin powder is reddish brown.3919 Intact vials should be stored at controlled room temperature and protected from excessive heat and light.3919 Depending on the specific product, the reconstituted solution is stable at room temperature for up to 24 or 30 hours;3919; 3920 specific product labeling should be consulted.
Solutions diluted in dextrose 5% are stated to be stable at room temperature for up to 4 or 8 hours, depending on the specific product; precipitation may occur beyond this time.3919; 3920 Solutions diluted in sodium chloride 0.9% are stated stable at room temperature for up to 6 or 24 hours, depending on the specific product.3919; 3920
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