AHFS Class:

48:48.24 Phosphodiesterase type 5 inhibitors

Generic Name

• Sildenafil Citrate (CAS Registry Number: 171599-83-0)

Sildenafil citrate injection is available in single-use vials containing 10 mg of sildenafil in 12.5 mL.³⁷⁶⁴ Each mL of solution contains the equivalent of 0.8 mg of sildenafil as the citrate salt and dextrose in water for injection.³⁷⁶⁴

Equivalency

Sildenafil citrate 1.124 mg is equivalent to 0.8 mg of sildenafil.³⁷⁶⁴

Trade Name(s)

Revatio

Sildenafil citrate injection is administered by intravenous bolus injection.³⁷⁶⁴

Sildenafil citrate injection is a clear, colorless solution.³⁷⁶⁴ Intact vials should be stored at controlled room temperature.³⁷⁶⁴ Vials are for single use only; unused portions should be discarded.³⁷⁶⁴

Syringes

Sildenafil citrate (Revatio) diluted in dextrose 5% to a concentration of 0.067 or 0.667 mg/mL was stored in 50-mL polypropylene syringes (Plastipak, Becton Dickinson) at 20 to 25°C and 37°C for 7 days.³⁷⁶⁵ The drug was found to be stable with less than 5% loss in 7 days at either storage temperature.³⁷⁶⁵

Filtration

Sildenafil citrate (Viatris) prepared at sildenafil concentrations of 60 and 600 mcg/mL in dextrose 5% was delivered as 4 mL of solution through 0.2- or 0.22-µm syringe filters composed of nylon (Phenomenex), polyethersulfone (Millex GP), or mixed cellulose esters (Millex GS), or a 0.2-µm polyethersulfone inline filter (Pall).⁴⁰⁵⁶ The concentration of sildenafil recovered in the filtrate was measured by HPLC and compared with that of unfiltered solution.⁴⁰⁵⁶ Although lower drug recovery was observed in the first mL of filtrate compared with subsequent milliliters, for the 600-mcg/mL solution, sildenafil recovery remained over 90% through all filters tested.⁴⁰⁵⁶ For the 60-mcg/mL solution, only the nylon syringe filter (Phenomenex) allowed for over 90% sildenafil recovery in the first mL of filtrate and subsequent milliliters.⁴⁰⁵⁶ For the polyethersulfone (Millex GP) and mixed cellulose ester (Millex GS) syringe filters and polyethersulfone inline filter (Pall), sildenafil recovery was below 80% in the first mL of filtrate but increased to over 90% for subsequent milliliters.⁴⁰⁵⁶

Additive Compatibility

Y-Site Injection Compatibility (1:1 Mixture)

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions March 7, 2025. © Copyright, 2025. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.