AHFS Class:

40:28.08 Loop Diuretics

Generic Name

• Bumetanide

Bumetanide is available as a 0.25-mg/mL solution in 4-mL single-dose vials and 10-mL multiple-dose vials.³²⁸⁸; ³³⁰⁹ The solution also contains sodium chloride 0.85%, ammonium acetate 0.4%, disodium edetate 0.01%, and benzyl alcohol 1% with sodium hydroxide to adjust the pH.³²⁸⁸; ³³⁰⁹

pH

Adjusted to approximately 7³²⁸⁸ or 6.8 to 7.8.³³⁰⁹

Bumetanide is administered by intramuscular injection,³²⁸⁸; ³³⁰⁹ direct intravenous injection over 1 to 2 minutes,³²⁸⁸; ³³⁰⁹ and by intravenous infusion.⁴

Bumetanide discolors when exposed to light. The injection should be stored at controlled room temperature and protected from light.³²⁸⁸; ³³⁰⁹ Bumetanide is reported to be stable at pH 4 to 10.⁴ Precipitation may occur at pH values less than 4.¹⁶⁴⁴

Sorption

Substantial sorption to glass and PVC containers does not occur.³²⁸⁸; ³³⁰⁹

Central Venous Catheter

Bumetanide (Ohmeda) 0.04 mg/mL prepared in dextrose 5% was found to be compatible with the ARROWg+ard Blue Plus (Arrow International) chlorhexidine-bearing triple-lumen central catheter. Essentially complete delivery of the drug was found with little or no drug loss occurring. Furthermore, chlorhexidine delivered from the catheter remained at trace amounts with no substantial increase due to the delivery of the drug through the catheter.²³³⁵

Standardize 4 Safety

One or more standardized concentrations for this drug have been established through Standardize 4 Safety (S4S), a national patient safety initiative to reduce medication errors, especially during transitions of care. (See Standardize 4 Safety in Users Guide.) Recommendations developed to date through this initiative are available at www.ashp.org/pharmacy-practice/standardize-4-safety-initiative.

Table 1. Standardize 4 Safety Continuous IV Infusion Standard Concentrations for Bumetanide³⁶³⁵; ³⁶³⁶

Solution Compatibility

Additive Compatibility

Drugs in Syringe Compatibility

Y-Site Injection Compatibility (1:1 Mixture)

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions December 5, 2024. © Copyright, 2024. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.