Prochlorperazine edisylate is available as a 5-mg/mL injection solution in 2-mL multiple-dose vials.1010 Each mL contains prochlorperazine 5 mg, monobasic sodium phosphate 5 mg, sodium tartrate 12 mg, saccharin sodium 0.9 mg, and benzyl alcohol 7.5 mg in water for injection.1010
pH
From 4.2 to 6.2.1010
Prochlorperazine edisylate may be administered intramuscularly deep into the upper outer quadrant of the buttock.1010 It also may be administered by slow intravenous injection at a rate not exceeding 5 mg/min.1010 It can be given undiluted or diluted in isotonic solution.1010 It should not be given as a bolus intravenous injection.1010 Because the drug causes local irritation, subcutaneous injection is not recommended.1010
Intact containers should be stored at controlled room temperature in the outer carton to protect from light.1010 Prochlorperazine edisylate injection is a colorless to slightly yellowish solution; discard if markedly discolored.1010
Dilution of prochlorperazine edisylate to a 1-mg/mL concentration with bacteriostatic sodium chloride 0.9% containing methyl- and propylparabens resulted in a distinctly cloudy solution. This cloudiness did not occur when sodium chloride 0.9% preserved with benzyl alcohol was used for the dilution.752
Light Effects
Prochlorperazine edisylate (Wyeth) 20 mg/L in dextrose 5% exhibited about 20% loss in 2 hours at room temperature when exposed to light. More rapid and extensive decomposition occurred when sodium chloride 0.9% was used as the diluent.2412
Filtration
Prochlorperazine edisylate (SKF) 5 mg/L in dextrose 5% and sodium chloride 0.9% did not display significant sorption to a 0.45-µm cellulose membrane filter.567
Central Venous Catheter
Prochlorperazine edisylate (SoloPak) 0.5 mg/mL in dextrose 5% was found to be compatible with the ARROWg+ard Blue Plus (Arrow International) chlorhexidine-bearing triple-lumen central catheter. Essentially complete delivery of the drug was found with little or no drug loss occurring. Furthermore, chlorhexidine delivered from the catheter remained at trace amounts with no substantial increase due to the delivery of the drug through the catheter.2335
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