Iron sucrose injection is available as a brown solution in 2.5-, 5-, and 10-mL single-dose (preservative-free) vials containing 50, 100, and 200 mg of elemental iron, respectively.3551 Each mL of the solution contains 20 mg of elemental iron and 300 mg of sucrose in water for injection.3551
pH
Iron sucrose injection has a pH ranging from 10.5 to 11.1.3551
Osmolarity
Iron sucrose injection has an osmolarity of 1250 mOsmol/L.3551
Trade Name(s)
Venofer
Iron sucrose is administered only intravenously, as an injection or an infusion.3551 Stable intravenous access should be insured to avoid extravasation.3551
In adults, doses of elemental iron up to 200 mg can be administered undiluted as a slow intravenous injection over 2 to 5 minutes; doses of 100 or 200 mg also may be administered as an intravenous infusion over at least 15 minutes following dilution of the dose in a maximum of 100 mL of sodium chloride 0.9%.3551 Doses of elemental iron of 300 or 400 mg should be administered as an intravenous infusion over 1.5 or 2.5 hours, respectively, following dilution of the dose in a maximum of 250 mL of sodium chloride 0.9%.3551 The manufacturer states that there is limited experience with the administration of 500-mg doses of elemental iron as an intravenous infusion over 3.5 to 4 hours following dilution of the dose in a maximum of 250 mL of sodium chloride 0.9%.3551
In pediatric patients 2 years of age or older, doses of elemental iron up to 100 mg can be administered undiluted as a slow intravenous injection over 5 minutes or as an intravenous infusion over 5 to 60 minutes following dilution of the dose to an elemental iron concentration of 1 to 2 mg/mL in sodium chloride 0.9%.3551
Iron sucrose injection should not be diluted to an elemental iron concentration of less than 1 mg/mL.3551
Intact vials of iron sucrose should be stored at controlled room temperature; freezing should be avoided.3551
Iron sucrose injection should not be diluted to an elemental iron concentration of less than 1 mg/mL.3551
Iron sucrose injection should be visually inspected for particulate matter and discoloration prior to administration.3551 The manufacturer states that iron sucrose injection should not be mixed with other drugs or added to parenteral nutrition solutions for intravenous infusion.3551
Syringes
Iron sucrose (American Regent) containing 20 mg/mL of elemental iron undiluted or diluted to concentrations ranging from 2 to 10 mg/mL in sodium chloride 0.9% and stored in plastic syringes was found to be physically and chemically stable for 7 days at 23 to 27°C and 2 to 6°C.3551
For a list of references cited in the text of this monograph, search the monograph titled References.