AHFS Class:

90:24.20.92 Interleukin-mediated Agents, Miscellaneous

Anakinra is available in prefilled glass syringes containing 100 mg of drug in 0.67 mL of solution.²⁸⁵⁹ The prefilled syringes have 27-gauge needles protected with latex rubber covers.²⁸⁵⁹ Each syringe containing 0.67 mL of solution also contains anhydrous citric acid 1.29 mg, sodium chloride 5.48 mg, disodium EDTA 0.12 mg, and 0.7 mg of polysorbate 80 in water for injection.²⁸⁵⁹

pH

6.5.²⁸⁵⁹

Trade Name(s)

Kineret

Anakinra is administered subcutaneously.²⁸⁵⁹

Anakinra should be stored under refrigeration.²⁸⁵⁹ Do not shake; protect from freezing and light. The injection contains no preservative and is for single use.²⁸⁵⁹ Discard any unused portions.²⁸⁵⁹

Visually inspect the syringes prior to use.²⁸⁵⁹ The solution may contain trace amounts of small, translucent to white, amorphous protein particles.²⁸⁵⁹ If the number of these particles appears excessive or the solution is discolored, cloudy, or particulate matter is present, the syringe should be discarded.²⁸⁵⁹

Y-Site Injection Compatibility (1:1 Mixture)

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions December 5, 2024. © Copyright, 2024. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.