Albumin human is available as a 5, 20, or 25% solution in single-dose vials or flexible plastic containers in sizes ranging from 20 to 500 mL.4086; 4087; 4088; 4089; 4090; 4091; 4092; 4093; 4094; 4095 Albumin human-kjda is available as a 5 or 25% solution in single-dose vials ranging in size from 50 to 500 mL.4089; 4090
The products are prepared by fractionation of pooled human plasma and are heat-treated for inactivation of viruses.4086; 4087; 4088; 4089; 4090; 4091; 4092; 4093; 4094; 4095
A 5% solution (50 mg/mL) contains albumin human 2.5, 12.5, or 25 grams in each 50-, 250-, or 500-mL container, respectively.4086; 4091; 4094; 4095 A 20% solution (200 mg/mL) contains albumin human 10 or 20 grams in each 50- or 100-mL container, respectively.4087; 4092 A 25% solution (250 mg/mL) contains albumin human 5, 12.5, or 25 grams in each 20-, 50-, or 100-mL container, respectively.4088; 4090; 4093 Albumin human products also contain sodium caprylate or caprylic acid and sodium acetyltryptophanate or N-acetyltryptophan as stabilizers.4086; 4087; 4088; 4089; 4090; 4091; 4092; 4093; 4094; 4095 Other excipients may include sodium chloride, potassium chloride, sodium hydroxide, and/or sodium acetate.4089; 4090; 4091; 4092; 4093; 4094; 4095
Sodium Content
Albumin human and albumin human-kjda: 145 mEq/L or from 130 to 160 mEq/L.4086; 4087; 4088; 4089; 4090; 4091; 4092; 4093; 4094; 4095
Aluminum Content
In general, albumin human and albumin human-kjda products are stated to contain no more than 200 mcg of aluminum per L.4086; 4087; 4088; 4089; 4090; 4091; 4092; 4093; 4094
Trade Name(s)
Albuminex, Alburx, Albutein, Buminate, Flexbumin, Plasbumin
Albumin human and albumin human-kjda are administered by intravenous infusion either undiluted or diluted in an appropriate infusion solution (e.g., sodium chloride 0.9% or dextrose 5%).4087; 4089; 4091; 4095 Do not dilute with sterile water for injection.4087; 4089; 4091; 4095 Potentially fatal hemolysis and acute renal failure may result from use of sterile water for injection as a diluent for albumin human or albumin human-kjda.4087; 4089; 4091; 4095
CAUTION—Substantial reduction in tonicity, creating the potential for fatal hemolysis and acute renal failure, may result from the use of sterile water as a diluent. The hemolysis and acute renal failure that result from the use of a sufficient volume of sterile water as a diluent may be life-threatening.4; 1942; 2072; 2073
Albumin human and albumin human-kjda products have been variously described as a clear and slightly viscous, almost colorless to yellow, amber, or green solution; or transparent or slightly opalescent, which may have a greenish tint or may vary from a pale straw to amber in color.4086; 4089; 4091; 4094; 4095 Do not use solutions that are turbid or contain particulate matter or sediment.4086; 4089; 4091; 4094; 4095
Intact containers should be stored at room temperature not exceeding 30°C.4086; 4089; 4091; 4094 Labeling for some products may state the storage temperature should not exceed 25°C.4095 Do not freeze.4086; 4089; 4091; 4095 Labeling for some products may also state to store vials in the outer carton to protect from light.4089
Albumin human and albumin human-kjda products contain no preservative and should be used within 4 hours of initial entry into the container.4086; 4089; 4091; 4094; 4095 Do not begin administration more than 4 hours after initial container entry.4086; 4089; 4091; 4094; 4095 Partially used containers should be discarded.4086; 4091; 4094; 4095
The addition of albumin human to parenteral nutrition solutions has resulted in occlusion of filters at concentrations ranging from over 25 g/L to 10.8 g/L.854; 1634
For a list of references cited in the text of this monograph, search the monograph titled References.