AHFS Class:

10:00 Antineoplastic Agents

Generic Name

• EriBULin Mesylate (CAS Registry Number: 441045-17-6)

Eribulin mesylate is available as a 0.5-mg/mL solution in 2-mL single-use vials containing a total of eribulin mesylate 1 mg (equivalent to eribulin 0.88 mg), dehydrated alcohol 5% (v/v), and water for injection 95% (v/v).³⁰²⁷; ³⁰²⁸ Sodium hydroxide and/or hydrochloric acid may have been added during manufacturing to adjust the pH.²⁸⁰⁵; ³⁰²⁸

pH

From 6.5 to 8.5.²⁸⁰⁵

Trade Name(s)

Halaven

Eribulin mesylate is administered intravenously over 2 to 5 minutes.³⁰²⁷ The drug may be administered undiluted or diluted in 100 mL of sodium chloride 0.9%.³⁰²⁷

Eribulin mesylate should not be diluted in dextrose-containing solutions nor administered through an intravenous line that is infusing dextrose-containing solutions.³⁰²⁷

Intact vials should be stored at controlled room temperature in the original carton; vials should not be refrigerated nor frozen.³⁰²⁷ Eribulin mesylate is a clear, colorless solution.³⁰²⁷

The manufacturer states that undiluted eribulin mesylate may be stored in a syringe for up to 4 hours at room temperature or up to 24 hours at 4°C.³⁰²⁷ Similarly, diluted solutions of eribulin mesylate may be stored for up to 4 hours at room temperature or 24 hours under refrigeration.³⁰²⁷ Unused portions remaining in the vials should be discarded.³⁰²⁷

Stability of the undiluted product (Eisai) was tested in the original glass vial with light protection at 25°C and at 2 to 8°C.³⁰²⁸ The solution was found to be physically compatible and chemically stable with little to no loss in 28 days.³⁰²⁸

pH Effects

Eribulin mesylate stability is pH dependent.³⁰²⁸ The drug has been noted to be stable over a pH range of 5 to 9.³⁰²⁸ Mixing eribulin mesylate with dextrose-containing solutions is not recommended given the acid sensitivity of the drug.³⁰²⁷; ³⁰²⁸

Syringes

Eribulin mesylate (Eisai) 205 mcg/mL in sodium chloride 0.9% packaged in 10-mL polypropylene syringes (Becton Dickinson) was physically compatible and chemically stable with little to no loss in 28 days stored with light protection at 25 and 2 to 8°C.³⁰²⁸

Solution Compatibility

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions March 31, 2024. © Copyright, 2025. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.