Rasburicase is available as a lyophilized powder in single-use vials containing 1.5 or 7.5 mg of the drug.3135 Each 1.5-mg vial also contains mannitol 10.6 mg, L-alanine 15.9 mg, and dibasic sodium phosphate in the range of 12.6 to 14.3 mg.3135 Each 7.5-mg vial also contains mannitol 53 mg, L-alanine 79.5 mg, and dibasic sodium phosphate in the range of 63 to 71.5 mg.3135 Each 1.5- or 7.5-mg vial of rasburicase is packaged with an ampul of special diluent containing 1 or 5 mL of water for injection, respectively, and poloxamer 188 1 or 5 mg, respectively.3135
The 1.5- and 7.5-mg vials of rasburicase must be reconstituted with 1 and 5 mL of the provided special diluent, respectively, for a solution with a final rasburicase concentration of 1.5 mg/mL.3135 Vials should be gently swirled until the contents are dissolved and should not be shaken or mixed so vigorously as to form a vortex.3135 Reconstituted solutions should be visually inspected for particulate matter prior to administration; if particulate matter is present or discoloration occurs, the solution should be discarded.3135 The appropriate dose of rasburicase should be withdrawn from the vial of reconstituted solution and further diluted in an infusion bag containing sodium chloride 0.9% to achieve a final total volume of 50 mL in the infusion bag.3135
Trade Name(s)
Elitek
Rasburicase is administered intravenously as an infusion over 30 minutes following dilution of the reconstituted solution.3135 Rasburicase should be infused through a separate line, or, if a common infusion line is being used to administer other drugs in addition to rasburicase, the line should be flushed with at least 15 mL of sodium chloride 0.9% prior to and following infusion of rasburicase.3135 Rasburicase should not be administered by bolus injection.3135
Rasburicase is a white to off-white powder.3135 Intact vials of rasburicase and accompanying ampuls of special diluent should be stored at 2 to 8°C and protected from light and freezing.3135
The reconstituted solution or solutions diluted for infusion in sodium chloride 0.9% should be stored at 2 to 8°C; reconstituted and diluted solutions should be discarded 24 hours after reconstitution.3135
Filtration
Filters should not be used during reconstitution or infusion of rasburicase.3135
For a list of references cited in the text of this monograph, search the monograph titled References.