Mexiletine hydrochloride is available as a 25-mg/mL solution in 10-mL (250-mg) ampuls. The product also contains sodium chloride and water for injection.38
Trade Name(s)
Mexitil
Mexiletine hydrochloride is administered intravenously. It should never be given as a bolus. A loading dose is given by intravenous injection at a rate of 1 mL (25 mg) per minute. This is followed by intravenous infusion of a 500-mg/500 mL (1-mg/mL) dilution in a suitable infusion solution. The initial infusion rate of the first 250 mL of the admixture is 4 mL/min over the first hour followed by infusion of the next 250 mL at 2 mL/min over the next two hours. Maintenance is performed using a 250-mg/500 mL (0.5-mg/mL) dilution administered at a rate of 1 mL/min.38
Mexiletine hydrochloride injection is a clear, colorless solution that should be stored below 25°C and protected from light. Dilutions for infusion are stable for up to eight hours.38
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